Advances in nanotechnology have shown great potential for generating new technologies and improving the quality of life, especially in the health area. Examples are: the production of more effective drugs and vaccines; and the development of integrated devices for early diagnosis, rapid analysis and personalized biomonitoring.
Nanostructured materials, micro/nanofabricated devices and computational methods play an essential role for scientific and technological advances in public, animal and environmental health. Thus, a deep understanding of the interactions of nanomaterials with biological systems (proteins, cells and microorganisms), as well as the structure of biomolecules and biomaterials, is fundamental for the discovery of biomarkers, pathologies treatments and safety protocols. Thus, it is necessary to advance in the study and control of phenomena at the nanoscale at the interface with complex biological systems.
The LNNano Health Program, in an integrated and multidisciplinary way, aims to create a differentiated and highly favorable environment for research at the frontier of knowledge, acting on three main fronts: i) sensors and biomonitoring, ii) nanobiointerfaces and iii) cryomicroscopy electronics. Thus providing unique opportunities for science, technology and innovation.
The following question guides the development of this program:
“What physicochemical phenomena occur at the nanoscale and how to produce functional materials/devices for interaction with complex biological systems for applications in health and life sciences?”
![Health_v2](https://lnnano.cnpem.br/wp-content/uploads/2021/07/Health_v2.png)
Projects
![PROJETOS - COVID-19](https://lnnano.cnpem.br/wp-content/uploads/2021/02/PROJETOS-COVID-19-1-scaled-e1614190365150.jpg)
COVID-19
- Construction of nanostructured platforms for the prevention and detection of COVID-19;
- Development of a low-cost biosensor for detection of COVID-19 in its early stages.
![PROJETOS - Sensores e dispositivos](https://lnnano.cnpem.br/wp-content/uploads/2021/02/PROJETOS-Sensores-e-dispositivos-1-scaled-e1614190456280.jpg)
Sensors and devices
- Biosensor for blood coagulation;
- Manufacturing and characterization of nanomembrane-based devices;
- Biosensor for measuring the glycemic index of human interstitial fluid;
- Multidimensional sensor for in-situ monitoring of nanoparticles.
![PROJETOS - NanoBioInfo](https://lnnano.cnpem.br/wp-content/uploads/2021/02/PROJETOS-NanoBioInfo-e1614190142533.jpg)
NanoBioInfo
- Study of Biomolecular corona formation on the surface of nanostructured materials: characterization and impact on cell interaction;
- Electrochemical characterization, machine learning and functional devices for biological applications and predictive nanotoxicology;
- CompSafeNano – NanoInformatics Approaches for Safe-by-Design of NanoMaterials.
![PROJETOS - Criomicroscopia](https://lnnano.cnpem.br/wp-content/uploads/2021/02/PROJETOS-Criomicroscopia-1-e1614190512742.png)
Cryomicroscopy
- Establishment of an Open Electron Cryomicroscopy Facility (Cryo-EM) at CNPEM;
- Biological complexes in action, in vitro and in silico (Exploring Big-Data in Cryo-EM).