LNNano - Brazilian Nanotechnology National Laboratory

Nanoarchitectonics in Microfluidic Devices for Sensing and Biosensing

Paulo A. Raymundo-Pereira, Flavio M. Shimizu, Renato S. Lima, Osvaldo N. Oliveira, Jr.

Instituto de Física de São Carlos, Universidade de São Paulo (USP), São Carlos, São Paulo 13560-970, Brasil.

Laboratório Nacional de Nanotecnologia (LNNano), Centro Nacional de Pesquisa em Energia e Materiais, Campinas (CNPEM), São Paulo 13083-970, Brasil.

ABSTRACT: The combination of nanoarchitectonics with microfluidic systems in analytical devices has brought about an innovative platform for sensing and biosensing. This chapter provides a general overview of materials and fabrication techniques in nanoarchitectonics, especially for bridging the gap between proof-of-principle experiments and commercialization. Emphasis is placed on biosensing based on impedance spectroscopy and electrochemical techniques for detecting proteins, genes and biomarkers, where microfluidics offers advantages such as low cost, automation, miniaturization, and high performance in terms of sensitivity and selectivity. Of special importance is the integration of microfluidic systems with diagnostic applications for point-of-care devices, which can also be envisaged with multiplexed detection in a single chip.

Chapter (number 3) of the book ‘Advanced Supramolecular Nanoarchitectonics’ published by Elsevier (DOI: 10.1016/B978-0-12-813341-5.00009-7). Keywords: Nanoarchitectonics; MOFs; Layer-by-layer; Lab-on-a-chip; Electronic tongues.