Graphene-Containing Microfluidic and Chip-Based Sensor Devices for Biomolecules
Elsa M. Materón,† Renato S. Lima,‡ Nirav Joshi,† Flavio M. Shimizu,†,‡ Osvaldo N. Oliveira, Jr.†
† Instituto de Física de São Carlos, Universidade de São Paulo (USP), São Carlos, São Paulo 13560-970, Brasil.‡ Laboratório Nacional de Nanotecnologia, Centro Nacional de Pesquisa em Energia e Materiais, Campinas, São Paulo 13083-970, Brasil.
ABSTRACT: Graphene-based microfluidic devices can be useful for biosensors and for studying biological systems owing to their comparable length scales and flow characteristics. In sensing and biosensing, the goal in microfluidics research is to develop integrated miniaturized devices capable of achieving high sensitivity and selectivity, rapid response, multiplexing, automation, and allow towards tests with a small sample volume. In this chapter, a description is presented of fabrication techniques of graphene and derivatives, particularly focused on their possible application in microfluidic devices. A major emphasis is placed on the challenges to reach point-of-care diagnostics, which requires considerably more extensive research as only a few graphene-related studies involving microfluidic devices are available in the literature.
Chapter (number 13) of the book ‘Graphene-Based Electrochemical Sensors for Biomolecules’, published by Elsevier (DOI: 10.1016/B978-0-12-815394-9.00013-3). Keywords: Graphene, Sensor, Biosensor, Microfluidic devices, Biomolecules.